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It should be noted that it is of no consequence that the data set used for estimates of PAF in 2010 is derived from study results pertaining to the period 19841988, so long as the two components (mortality/incidence of lung cancer in non-smokers, and relative risks of different cancers in smokers vs never-smokers) derive from the same population

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Irreparably damaged mtDNA may trigger mitophagy [425], and accumulation of mtDNA damage can impair mitophagy gene expression and signaling [426]

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